research and DEVELOPMENT
신경질환 혁신신약
유전자 치료
CRISPR
샤르코마리투스병 관련 정보

Viader A, Sasaki Y, Kim S, Strickland A, Workman CS, Yang K, Gross RW, Milbrandt J. Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy. Neuron. 2013 Mar 6;77(5):886-98. doi: 10.1016/j.neuron.2013.01.012. PubMed PMID: 23473319; PubMed Central PMCID: PMC3594792.
Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Sci Rep. 2016 Mar 18;6:23326. doi: 10.1038/srep23326. PubMed PMID: 26987296; PubMed Central PMCID: PMC4796910.
Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J. Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity. J Neurosci. 2016 Sep 14;36(37):9633-46. doi: 10.1523/JNEUROSCI.1235-16.2016. PubMed PMID: 27629714; PubMed Central PMCID: PMC5039245.
Sasaki Y, Hackett AR, Kim S, Strickland A, Milbrandt J. Dysregulation of NAD+ Metabolism Induces a Schwann Cell Dedifferentiation Program. J Neurosci. 2018 Jul 18;38(29):6546-6562. doi: 10.1523/JNEUROSCI.3304-17.2018. Epub 2018 Jun 19. PubMed PMID: 29921717; PubMed Central PMCID: PMC6052240.
Kim S, Maynard JC, Strickland A, Burlingame AL, Milbrandt J. Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):8019-8024. doi: 10.1073/pnas.1805538115. Epub 2018 Jul 16. PubMed PMID: 30012597; PubMed Central PMCID: PMC6077742.
Jang HS, Shah NM, Du AY, Dailey ZZ, Pehrsson EC, Godoy PM, Zhang D, Li D, Xing X, Kim S, O’Donnell D, Gordon JI, Wang T. Transposable elements drive widespread expression of oncogenes in human cancers. Nat Genet. 2019 Apr;51(4):611-617. doi: 10.1038/s41588-019-0373-3. Epub 2019 Mar 29. PubMed PMID: 30926969; PubMed Central PMCID: PMC6443099.